Getting My ceesdekker To Work
Getting My ceesdekker To Work
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Making use of solitary-molecule optical and AFM imaging and power-spectroscopy methods, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our exploration pursuits incorporate:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
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Because 2000, Dekker has shifted the leading focus of his perform toward biophysics in which he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This change of area was driven by his fascination for that extraordinary functioning of biological molecular structures, and also via the long-phrase viewpoint that lots of appealing discoveries is usually anticipated On this subject.[five] Latest strains of investigate in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
The coiled-coil of your human Rad50 DNA mend protein consists of specific segments of greater versatility
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with analysis from DNA supercoiling research of nucleosomes and DNA repair proteins to DNA translocation as a result of nanopores. Not long ago his analysis has focused on studying mobile division with germs on chip, while his top fascination is within the way of noticing synthetic cells.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA in a cooperative style
Comprehension elementary procedures regulating the spatial and dynamic organisation with the DNA in Stay cells.
‘The fantastically delicate way during which components in nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I count on that my amazement for ceesdekker the complexity of development will have elevated and with it my awe for the greatness with the Creator.’
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2001, discovery of solitary-electron transistors at space temperature determined by nanotubes; realization of 1st logic circuits with carbon nanotube products; and discovery of your molecular composition of DNA repair enzymes with AFM
Allow’s 1st glance again for the time being whenever you chose to shift your target from superconductivity and nanotubes to biology at the end of the nineties.
The biophysicist from Delft – who has long been one of the most cited researchers while in the Netherlands For a long time – can take his accountability to contribute to the rationalization and popularisation of his operate on the border of physics and biology very seriously and consistently appears within the media; Otherwise to mention his function, then about the connection amongst science and his Christian faith.